9-[2-O-Acetyl-3-azido-3-deoxy-5-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine [2095417-30-2]

MedChem Express

9-[2-O-Acetyl-3-azido-3-deoxy-5-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine [2095417-30-2]

10

2095417-30-2

Research Use Only

C20H18ClN7O5

471.85

9-[2-O-Acetyl-3-azido-3-deoxy-5-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 9-[2-O-Acetyl-3-azido-3-deoxy-5-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

ClC1=C(C2=NC=N1)N=CN2[C@@H]3[C@@H](OC(C)=O)[C@@H](N=[N+]=[N-])[C@H](COC(C4=CC=C(C)C=C4)=O)O3

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