9(R)-HODE [10075-11-3]

MedChem Express

9(R)-HODE [10075-11-3]

5

10075-11-3

Research Use Only

C18H32O3

296.44

9(R)-HODE (9(R)-Hydroxyoctadecadienoic acid) is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3alpha- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 microg/mL.

CCCCC/C=C\C=C\[C@H](O)CCCCCCCC(O)=O

12352200