A-176120 [185049-54-1]
HY-117807
CAS Number185049-54-1
Product group Chemicals
Molecular Weight583.58
Overview
- SupplierMedChem Express
- Product NameA-176120 [185049-54-1]
- Delivery Days Customer5
- CAS Number185049-54-1
- CertificationResearch Use Only
- Molecular FormulaC33H29NO9
- Molecular Weight583.58
- Scientific DescriptionA-176120 is a selective inhibitor of farnesyl transferase (IC50=1.2 nM) based on a farnesyl pyrophosphate (FPP) analog, with superior selectivity against GGTaseI (IC50=423 nM), GGTaseII (IC50=3000 nM), and SSase (IC50>10 microM). A-176120 inhibits ras processing in H-ras transformed NIH3T3 cells and HCT116 K-ras mutant cells (ED50=1.6 and 0.5 microM, respectively). A-176120 has antiangiogenic and antitumor activities in vivo and reduces capillary structure formation and VEGF secretion[1].
- SMILESO=C(C1=CC(C(N(CC2=CC=CC=C2OCC)CC3=CC=CC(OC4=CC=C(C)C=C4)=C3)=O)=C(C(O)=O)C=C1C(O)=O)O
- UNSPSC12352200