A-331440 [392338-13-5]
HY-12191
CAS Number392338-13-5
Product group Chemicals
Molecular Weight349.47
Overview
- SupplierMedChem Express
- Product NameA-331440 [392338-13-5]
- Delivery Days Customer5
- CAS Number392338-13-5
- CertificationResearch Use Only
- Molecular FormulaC22H27N3O
- Molecular Weight349.47
- Scientific DescriptionA-331440 is a potent and selective histamine H3 receptor antagonist that regulates neurotransmitter release by inhibiting presynaptic H3 receptors. In preclinical studies involving mice on a high-fat diet, A-331440 demonstrated dose-dependent effects on weight reduction and fat loss. At 5 mg/kg, it effectively decreased body weight comparable to dexfenfluramine, while at 15 mg/kg, it significantly reduced body fat and improved insulin tolerance, similar to mice on a low-fat diet. These findings suggest that A-331440 holds promise as an antiobesity agent by modulating histaminergic pathways involved in food intake and metabolic regulation[1].
- SMILESCN(C)[C@H](CC1)CN1CCCOC2=CC=C(C3=CC=C(C=C3)C#N)C=C2
- UNSPSC12352200