A-424274 [1335145-56-6]
HY-116149
CAS Number1335145-56-6
Product group Chemicals
Molecular Weight225.29
Overview
- SupplierMedChem Express
- Product NameA-424274 [1335145-56-6]
- Delivery Days Customer9
- CAS Number1335145-56-6
- CertificationResearch Use Only
- Molecular FormulaC14H15N3
- Molecular Weight225.29
- Scientific DescriptionA-424274 is a positive allosteric modulator of the alpha4beta2 neuronal nicotinic acetylcholine receptor with activity to enhance the efficacy of analgesics. A-424274 selectively enhances the potency of a range of nicotinic acetylcholine receptor agonists at the alpha4beta2 receptor and, in preclinical models, co-administration with an alpha4beta2 PAM significantly enhances the analgesic efficacy of ABT-594 at clinically well-tolerated doses in humans.
- SMILES[H][C@]12CN(C3=CC4=CC=CC=C4N=C3)C[C@@]1([H])NC2
- UNSPSC12352200