A 62176 (hydrochloride)

MedChem Express

A 62176 (hydrochloride)

9

Research Use Only

C20H17ClFN3O4

417.82

A 62176 hydrochloride is a compound that targets DNA topoisomerase II and has the activity of inhibiting purine synthesis in cancer cells. A 62176 hydrochloride interferes with c-MYC mRNA expression by interacting with G-quadruplex. The main mechanism of action of A 62176 hydrochloride is by displacing nucleosomes from the quadruplex of non-template strand rDNA, resulting in rapid redistribution of nucleosomes. The application potential of A 62176 hydrochloride is that it causes DNA damage and relies on BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways to repair the damage[1].

O=C(C1=CN2C3=C(OC4=C2C(C1=O)=CC(F)=C4N5CCC(C5)N)C=CC=C3)O.Cl

12352200