A-674563 2HCl(552325-73-2(fb-2hcl))

Biorbyt

A-674563 2HCl(552325-73-2(fb-2hcl))

10

Research Use Only

>98%

C22H24Cl2N4O

431.4

A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and > 30-fold selective for Akt1 over PKC.A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro (EC50: 0.4 microM) [1]. A563 (0-10 microM) markedly decreases GSK3 and MDM2 phosphorylation in STS cells.

-20°C

12352200