A-770041

MedChem Express

A-770041 [869748-10-7]

10

869748-10-7

Research Use Only

99.95

C34H39N9O3

621.73

A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 inhibits Lck with an IC 50 value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the other Src family kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection [1] [2] .

NC1=C2C(N([C@@H]3CC[C@@H](N4CCN(C(C)=O)CC4)CC3)N=C2C5=CC=C(NC(C6=CC7=C(C=CC=C7)N6C)=O)C(OC)=C5)=NC=N1

-20°C,2°C to 8°C

12352200