Chemical Structure
Chemical Structure
A 83-01
M5037
CAS Number909910-43-6
Product group Chemicals
Estimated Purity>99.0%
Molecular Weight421.52
Overview
- SupplierAbMole BioScience
- Product NameA 83-01
- Delivery Days Customer9
- CAS Number909910-43-6
- CertificationResearch Use Only
- Estimated Purity>99.0%
- Molecular FormulaC25H19N5S
- Molecular Weight421.52
- Scientific DescriptionA-83-01, an inhibitor of TGF-β type I receptor, increased the expression of Myf5 and MyoD, and enhanced myotube formation.The targeting efficacy of single intravenous injections of F-SL combined with A-83-01 was evaluated by measurement of the biodistribution and the antitumor effect in mice bearing murine lung carcinoma M109. A-83-01 temporarily changed the tumor vasculature around 3 h post injection. A-83-01 induced 1.7-fold higher compound accumulation of F-SL in the tumor than liposome alone at 24 h post injection.
- SMILESCC1=CC=CC(=N1)C2=N[N](C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
- Storage Instruction-20°C, protect from light, dry, sealed
- UNSPSC12352200
References
- Yang H, Cheng J, Zhuang H, et al. Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer. Cancer Cell. 2024,42(4):535-551.e8. doi: 10.1016/j.ccell.2024.03.004Read this paper
- Wei D, Yuan L, Xu X, et al. Exploring epigenetic dynamics unveils a super-enhancer-mediated NDRG1-β-catenin axis in modulating gemcitabine resistance in pancreatic cancer. Cancer Lett. 2024,605:217284. doi: 10.1016/j.canlet.2024.217284Read this paper
- Tu R, Ma J, Chen Y, et al. USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression. Cell Death Dis. 2024,15(10):749. doi: 10.1038/s41419-024-07136-0Read this paper
- Xu J, Gong J, Li M, et al. Gastric cancer patient-derived organoids model for the therapeutic drug screening. Biochim Biophys Acta Gen Subj. 2024,1868(4):130566. doi: 10.1016/j.bbagen.2024.130566Read this paper
Datasheet
MSDS
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