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Chemical Structure
Chemical Structure
Chemical Structure

A 83-01 [909910-43-6]

M5037
AbMole BioScience
CAS Number909910-43-6
Product group Chemicals
Estimated Puritymore then99.0%
Molecular Weight421.52
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    A 83-01 [909910-43-6]
  • Delivery Days Customer
    7
  • CAS Number
    909910-43-6
  • Certification
    Research Use Only
  • Estimated Purity
    more then99.0%
  • Molecular Formula
    C25H19N5S
  • Molecular Weight
    421.52
  • Scientific Description
    A 83-01 is a selective inhibitor of TGF-bèta type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).*The compound is unstable in solutions, freshly prepared is recommended
  • SMILES
    CC1=CC=CC(=N1)C2=N[N](C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
  • Storage Instruction
    -20°C, protect from light, dry, sealed
  • UNSPSC
    12161500

References

  • Yang H, Cheng J, Zhuang H, et al. Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer. Cancer Cell. 2024,42(4):535-551.e8. doi: 10.1016/j.ccell.2024.03.004
    Read this paper
  • Wei D, Yuan L, Xu X, et al. Exploring epigenetic dynamics unveils a super-enhancer-mediated NDRG1-β-catenin axis in modulating gemcitabine resistance in pancreatic cancer. Cancer Lett. 2024,605:217284. doi: 10.1016/j.canlet.2024.217284
    Read this paper
  • Tu R, Ma J, Chen Y, et al. USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression. Cell Death Dis. 2024,15(10):749. doi: 10.1038/s41419-024-07136-0
    Read this paper
  • Xu J, Gong J, Li M, et al. Gastric cancer patient-derived organoids model for the therapeutic drug screening. Biochim Biophys Acta Gen Subj. 2024,1868(4):130566. doi: 10.1016/j.bbagen.2024.130566
    Read this paper

Datasheet

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MSDS

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