A031 [2682255-44-1]

MedChem Express

A031 [2682255-44-1]

10

2682255-44-1

Research Use Only

C50H61ClN10O7S

981.60

A031 is a highly effective PROTAC androgen receptor (AR) degrader with an IC50 value less than 0.25 microM for AR protein degradation. A031 has an inhibitory effect on tumor growth in zebrafish with human prostate cancer (VCaP)[1].

O=C(N([C@@H]1C2)[C@H](CC1)C[C@@H]2OC3=CC(Cl)=C(C=C3)C#N)C4=CN=C(N5CCN(CC5)CCOCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)N=C4

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