A1874

AbMole BioScience

A1874

9

2064292-12-0

Research Use Only

C58H62Cl3F2N9O7S

1173.59

A1874 is a BRD4-degrading PROTAC which inhibits many cancer cell lines proliferation, with DC50 of 32 nM (induce BRD4 degradation in cells).

COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=C(F)C=C(Cl)C=C4)C=CC(=C1)C(=O)NCCOCCOCCOCCNC(=O)CC5N=C(C6=CC=C(Cl)C=C6)C7=C(SC(=C7C)C)[N]8C(=NN=C58)C

2-8°C, dry, sealed

12352200