A2AR-antagonist-1 [2922920-71-4]
HY-149916
Overview
- SupplierMedChem Express
- Product NameA2AR-antagonist-1 [2922920-71-4]
- Delivery Days Customer10
- CAS Number2922920-71-4
- CertificationResearch Use Only
- Molecular FormulaC27H25N5O2
- Molecular Weight451.52
- Scientific DescriptionA2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC50=29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t1/2=86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2)[1].
- SMILESO=C(N(CC1=CC=CC(C(O)(C)C)=C1)C=C2)C=C2C3=NC(N)=NC(C4=C(C)C(C#N)=CC=C4)=C3
- UNSPSC12131703