Bio-Connect

A2AR-antagonist-1 [2922920-71-4]

HY-149916
MedChem Express
CAS Number2922920-71-4
Product group Chemicals
Molecular Weight451.52
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Overview

  • Supplier
    MedChem Express
  • Product Name
    A2AR-antagonist-1 [2922920-71-4]
  • Delivery Days Customer
    10
  • CAS Number
    2922920-71-4
  • Certification
    Research Use Only
  • Molecular Formula
    C27H25N5O2
  • Molecular Weight
    451.52
  • Scientific Description
    A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC50=29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t1/2=86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2)[1].
  • SMILES
    O=C(N(CC1=CC=CC(C(O)(C)C)=C1)C=C2)C=C2C3=NC(N)=NC(C4=C(C)C(C#N)=CC=C4)=C3
  • UNSPSC
    12131703