A769662 --- AMPK Activator

Bioss

A769662 --- AMPK Activator [844499-71-4]

16

Research Use Only

98.0

A769662 is a potent and selective small-molecule activator of AMP-activated protein kinase (AMPK). It induces allosteric activation of AMPK and inhibition of dephosphorylation of AMPK on Thr-172, similar to the effects of AMP. The activation of AMPK inhibits mTOR signaling, which is a positive effector of cell growth and survival. A769662 stimulated partially purified rat liver AMPK with an EC50 of 0.8 microM and inhibited fatty acid synthesis in primary rat hepatocytes with an IC50 of 3.2 microM. It can also stimulate Na+, K+-ATPase activity in skeletal muscle cells.

-20°C

51202000