Western Blot Positive WB detected in: Mouse kidney tissue All lanes: AAK1 antibody at 2.5ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 104, 94 kDa Observed band size: 104 kDa
Western Blot Positive WB detected in: Mouse kidney tissue All lanes: AAK1 antibody at 2.5ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 104, 94 kDa Observed band size: 104 kDa
AAK1 Antibody
CSB-PA643571LA01HU
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetAAK1
Overview
- SupplierCusabio
- Product NameAAK1 Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID22848
- Target nameAAK1
- Target descriptionAP2 associated kinase 1
- Target synonymsadaptor-associated kinase 1; AP2-associated protein kinase 1
- HostRabbit
- IsotypeIgG
- Protein IDQ2M2I8
- Protein NameAP2-associated protein kinase 1
- Scientific DescriptionRegulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C
- UNSPSC12352203