Western Blot Positive WB detected in: Mouse kidney tissue All lanes: AAK1 antibody at 2.5ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 104, 94 kDa Observed band size: 104 kDa

AAK1 Antibody

Name: AAK1 Antibody
SKU: CSB-PA643571LA01HU_C90
Availability: BackOrder

CSB-PA643571LA01HU

ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Product group Antibodies

ReactivityHuman, Mouse

TargetAAK1

Overview

Supplier
Cusabio
Product Name
AAK1 Antibody
Delivery Days Customer
20
Applications
ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID22848
Target name
AAK1
Target description
AP2 associated kinase 1
Target synonyms
adaptor-associated kinase 1; AP2-associated protein kinase 1
Host
Rabbit
Isotype
IgG
Protein IDQ2M2I8
Protein Name
AP2-associated protein kinase 1
Scientific Description
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

AAK1 Antibody

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Overview

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