AAK1/HDACs-IN-1

MedChem Express

AAK1/HDACs-IN-1

5

Research Use Only

C21H14N4O2

354.36

AAK1/HDACs-IN-1 (Compound 12) is the dual inhibitor for AAK1 and HDAC, that inhibits AAK1, HDAC1, and HDAC6 with IC50s of 15.9, 148.6, and 5.2 nM, respectively. AAK1/HDACs-IN-1 inhibits SARS-CoV-2 infection, suppresses the endocytosis of ACE2-SARS-CoV-2 complex, as well as AP2M1-ACE2 interaction[1].

ONC(C1=CC=C(C=C1)C2=CN=C3NC=C(C3=C2)C#CC4=CN=CC=C4)=O

12352200