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AAV3 Luciferase-eGFP

AAV3 Luciferase-eGFP

Research Use Only
78463
BPS Bioscience
Product group Molecular Biology
Price on request
Packing Size
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    AAV3 Luciferase-eGFP
  • Delivery Days Customer
    7
  • Certification
    Research Use Only
  • Scientific Description
    Adeno-Associated Virus Serotype 3 (AAV3) shares 82% sequence homology with AAV2, and like AAV2, requires Heparan Sulfate Proteoglycan (HSPG) for cellular attachment. AAV3 vectors transduce human liver cancer cells extremely efficiently because AAV3 utilizes the human Hepatocyte Growth Factor Receptor (hHGFR) as a co-receptor for viral entry, which is highly expressed in these cells. Both the extracellular domain and the intracellular kinase domain of hHGFR are required for AAV3-mediated transgene expression. These AAV3 particles constitutively express the firefly (Photinus pyralis) luciferase and eGFP genes connected via a T2A linker, under the control of a CMV promoter. The T2A self-cleaving peptide (derived from Thosea asigna virus 2A) leads to the efficient cleavage of the transcript, and expression of luciferase and eGFP as two separate proteins.
  • Storage Instruction
    -80°C
  • UNSPSC
    12352200

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