ABCB1-IN-2

MedChem Express

ABCB1-IN-2

9

Research Use Only

C29H29N3O6S

547.62

ABCB1-IN-2 (compound 16q) is a functional inhibitor that can directly bind to the ABCB1 protein and stabilize its structure without affecting the expression and subcellular localization of ABCB1. ABCB1-IN-2 can increase the sensitivity of MCF-7/ADR cells to paclitaxel (PTX), increase the accumulation of PTX, and prevent the accumulation and excretion of luciferin Rh123 mediated by ABCB1. ABCB1-IN-2, as an ABCB1-mediated multidrug resistance (MDR) reversal agent, shows a strong ability to reverse MDR[1].

COC1=C(OC)C(OC)=CC(C2=C(C3=CC(OC)=C(OC)C(OC)=C3)C(C)=NC4=CC(C5=CC=CS5)=NN24)=C1

12352200