ABCB1-IN-3
HY-168921
Molecular Weight288.34
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameABCB1-IN-3
- Delivery Days Customer5
- CertificationResearch Use Only
- Molecular FormulaC19H16N2O
- Molecular Weight288.34
- Scientific DescriptionABCB1-IN-3 (Compound K27) is an orally active inhibitor of ABCB1, and induces apoptosis. ABCB1-IN-3 directly binds to ABCB1 to inhibit efflux function, ensuring stable intracellular concentration of Paclitaxel (PTX) (HY-B0015) without affecting ABCB1 normal expression. ABCB1-IN-3 significantly increases the sensitivity of ABCB1-mediated multidrug resistance (MDR) to Paclitaxel in vitro, enhances cell cycle arrest, and inhibits proliferation. BCB1-IN-3 combined with Paclitaxel exhibits potent tumor suppression in vivo without generating toxicity[1].
- SMILESCN1C2=CC=CC=C2C3=C1C(C4=CC=C(OC)C=C4)=NC=C3
- UNSPSC12352200