Abrocitinib

MedChem Express

Abrocitinib [1622902-68-4]

10

1622902-68-4

99.26

C14H21N5O2S

323.41

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC 50 s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 ( IC 50 , 1.253 microM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease [1] .

CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2

-20°C,2°C to 8°C

12352200