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PF-04965842

Research Use Only
M8090
AbMole BioScience
CAS Number1622902-68-4
Product group Chemicals
Molecular Weight323.41
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    PF-04965842
  • Delivery Days Customer
    9
  • CAS Number
    1622902-68-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C14H21N5O2S
  • Molecular Weight
    323.41
  • Scientific Description
    Abrocitinib is an orally active and selective JAK1 inhibitor with an IC50 value of 29 nM. Abrocitinib reversibly inhibits JAK1 kinase by blocking its ATP-binding site. Abrocitinib (PF-04965842) inhibited TYK2 activity (IC50, 1.253 uM) and phosphorylation of STAT1, STAT3, and STAT5 after stimulation. It can be used in the study of autoimmune diseases.
  • SMILES
    CCC[S](=O)(=O)NC1CC(C1)N(C)C2=C3C=C[NH]C3=NC=N2
  • UNSPSC
    12352200