AC-4-130

MedChem Express

AC-4-130 [1834571-82-2]

10

1834571-82-2

Research Use Only

99.93

C37H36ClF5N2O5S

751.20

AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML) [1] .

FC1=C(C(F)=C(C(F)=C1F)S(=O)(N(CC2=CC=C(C=C2)Cl)CC(N(C3=CC=C(C=C3)C(O)=O)CC4=CC(C(C)(C)C)=CC(C(C)(C)C)=C4)=O)=O)F

-20°C,2°C to 8°C

12352200