AChE/Abeta-IN-2

MedChem Express

AChE/Abeta-IN-2

14

Research Use Only

C20H25ClN4

356.89

AChE/Abeta-IN-2 (compound 33) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC 50 of 135 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC 50 of 5.054 microM. AChE/Abeta-IN-2 also inhibits Abeta aggregation and shows good blood-brain barrier permeability. AChE/Abeta-IN-2 improves cognitive and spatial memory impairment in rats model [1] .

ClC1=CC=C(C=C1)CN2C=C(N=N2)CNC34CC(C5)CC(C4)CC5C3

12352200