ACHP [406208-42-2]

MedChem Express

ACHP [406208-42-2]

5

406208-42-2

Research Use Only

C21H24N4O2

364.44

ACHP (compound 4j) is a selective and orally active IkappaB kinase inhibitor with IC50 values of 8.5 nM and 250 nM for IKKbeta and IKKalpha, respectively. ACHP can effectively inhibit the STAT3 signaling pathway and induce cancer cell cycle arrest and apoptosis. ACHP shows anti-inflammatory activity in a mouse ear edema model. ACHP can be used in anti-inflammatory and anti-cancer (such as multiple myeloma and leukemia) studies[1][2][3][4].

NC1=NC(C(C(O)=CC=C2)=C2OCC3CC3)=CC(C4CCNCC4)=C1C#N

12352200