ACHP

MedChem Express

ACHP [406208-42-2]

5

406208-42-2

Research Use Only

C21H24N4O2

364.44

ACHP (compound 4j) is a selective and orally active IkappaB kinase inhibitor with IC 50 values of 8.5 nM and 250 nM for IKKbeta and IKKalpha , respectively. ACHP can effectively inhibit the STAT3 signaling pathway and induce cancer cell cycle arrest and apoptosis . ACHP shows anti-inflammatory activity in a mouse ear edema model. ACHP can be used in anti-inflammatory and anti-cancer (such as multiple myeloma and leukemia) studies [1] [2] [3] [4] .

NC1=NC(C(C(O)=CC=C2)=C2OCC3CC3)=CC(C4CCNCC4)=C1C#N

12352200