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ProductsBack/Actagardin [59165-34-3]
Chemical Structure
Chemical Structure
Chemical Structure

Actagardin [59165-34-3]

Research Use Only
AG-CN2-0300
AdipoGen Life Sciences
CAS Number59165-34-3
DownloadMSDS
Product group Chemicals
Estimated Purity>80%
Molecular Weight1890.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Actagardin
  • Delivery Days Customer
    10
  • CAS Number
    59165-34-3
  • Certification
    Research Use Only
  • Estimated Purity
    >80%
  • Molecular Formula
    C81H124N20O24S4
  • Molecular Weight
    1890.2
  • Scientific Description
    Chemical. CAS: 59165-34-3. Formula: C81H124N20O24S4. MW: 1890.2. Isolated from Actinoplanes sp. Tetracyclic class II lantibiotic. Structurally related to mersacidine. Antibiotic. Antibacterial against Gram-positive bacteria and Gram-negative microorganisms. Specifically inhibits peptidoglycan synthesis in the cell wall of Gram-positive bacteria, resulting in the accumulation of both uridine 5-disphosphate-N-acetylmuramylpentapeptide and lipid II. Has the ability to form a complex with lipid intermediate II (lipid II). - Tetracyclic class II lantibiotic. Structurally related to mersacidine. Antibiotic. Antibacterial against Gram-positive bacteria and Gram-negative microorganisms. Specifically inhibits peptidoglycan synthesis in the cell wall of Gram-positive bacteria, resulting in the accumulation of both uridine 5-disphosphate-N-acetylmuramylpentapeptide and lipid II. Has the ability to form a complex with lipid intermediate II (lipid II).
  • SMILES
    O=C(NC(C(C)C)C(NC1C(NC(C(NC(CC(C)C)C(NC(C(C)SCC2NC3=O)C(NC(C(C)CC)C(NC4CCC(O)=O)=O)=O)=O)=O)C(SCC(C(NCC(NC(C(S(CC(C(O)=O)NC(C(NC2=O)C)=O)=O)C)C(NC(C(C)C)C(NC3C(C)CC)=O)=O)=O)=O)NC4=O)C)=O)=O)C(NC(CNC(C(CO)NC(C(N)CSC1)=O)=O)=O)CC5=CNC6=C5C=CC=C6
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Gardimycin, a new antibiotic from Actinoplanes. I. Description of the producer strain and fermentation studies: F. Parenti, et al.; J. Antibiot. 29, 501 (1976)
  • Gardimycin, a new antibiotic from Actinoplanes. II Isolation and preliminary characterisation: C. Coronelli, et al.; J. Antibiot. 29, 507 (1976)
  • The Three-Dimensional Solution Structure of the Lantibiotic Murein-Biosynthesis-Inhibitor Actagardine Determined by NMR: N. Zimmermann & G. Jung; Eur. J. Biochem. 246, 809 (1997)
  • New insights into the mechanism of action of lantibiotics - Diverse biological effects by binding to the same molecular target: H. Brötz & H.G. Sahl; J. Antimicr. Chemother. 46, 1 (2000)
  • Lantibiotics produced by Actinobacteria and their potential applications (a review): K. Machado Gomes, et al.; Microbiol. 163, 109 (2017)