ADAM10 antibody

GeneTex

ADAM10 antibody

9

WB: 1 - 2 microg/mL. ICC/IF: 2-10 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ADAM10

ADAM metallopeptidase domain 10

AD10, AD18, CD156c, CDw156, HsT18717, MADM, RAK, kuz, disintegrin and metalloproteinase domain-containing protein 10, a disintegrin and metalloprotease domain 10, kuzbanian protein homolog, mammalian disintegrin-metalloprotease

Rabbit

IgG

Disintegrin and metalloproteinase domain-containing protein 10

Proinflammatory cytokine tumor necrosis factor-a (TNF-a)contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, Respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4).

Human

-20°C or -80°C,2°C to 8°C

41116161