Adenosine receptor antagonist 6
HY-175195
Molecular Weight332.36
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameAdenosine receptor antagonist 6
- Delivery Days Customer999
- CertificationResearch Use Only
- Molecular FormulaC18H16N6O
- Molecular Weight332.36
- Scientific DescriptionAdenosine receptor antagonist 6 is an orally active and selective A2A adenosine receptor (A2AAR) antagonist, with a Ki of 19.18 nM. Adenosine receptor antagonist 6 inhibits 5-N-ethylcarboxamide adenosine (NECA) (HY-103173)-mediated cAMP production (IC50 = 0.089 microM) and immunosuppression, while promoting IL-2 and IFN-gamma secretion. Adenosine receptor antagonist 6 abolishes the immunosuppressive effects of adenosine on T-cell activation and cytokine release. Adenosine receptor antagonist 6 inhibits tumor growth in a CT26/MC38 xenograft model. Adenosine receptor antagonist 6 can be used for the study of colon cancer[1].
- SMILESO=C(C1=CN2C3=CC=CC=C3N=C2C(N)=N1)N[C@@H](C)C4=NC=CC=C4
- UNSPSC12352200