ADENOVIRUS-BRCA1
1351
ApplicationsOther Application
Product group Expression
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Overview
- SupplierVector Biolabs
- Product NameADENOVIRUS-BRCA1
- Delivery Days Customer5
- ApplicationsOther Application
- CertificationResearch Use Only
- Concentration1E10 PFU/ml
- Scientific DescriptionThe breast cancer susceptibility gene, BRCA1, which maps to chromosome 17q is expressed in numerous tissues, including breast and ovary. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast and ovarian cancer. Mutations within the BRCA1 gene may account for at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. This adenovirus expresses the human BRCA1 transcript variant 5 (NM_007299). This variant differs in the 5 UTR, uses two alternate in-frame splice sites in the central coding region, and lacks an alternate exon in the 3 coding region that results in a frameshift, compared to variant 1. So this variant is shorter and has a distinct C-terminus, compared to BRCA1 isoform 1.
- Storage Instruction-80°C
- UNSPSC41106621