ADENOVIRUS-CDK5
1520
ApplicationsOther Application
Product group Expression
Product 1520 is not available
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Overview
- SupplierVector Biolabs
- Product NameADENOVIRUS-CDK5
- Delivery Days Customer5
- ApplicationsOther Application
- CertificationResearch Use Only
- Concentration1E10 PFU/ml
- Scientific DescriptionCyclin dependent kinases (Cdks) are critical regulators of cell cycle progression that are constitutively expressed throughout the cell cycle. Family members include Cdc2 p34, Cdk2-9, PITSLRE, PCTAIRE-1-3, KKIAMRE, KKIALRE and NKIAMRE. Prototype members of this family include Cdc2 p34 and Cdk2, which function late in the cell cycle, whereas other members, Cdk4, Cdk6 and a related protein Cdc7, are critically involved in the G1 and S phase transitions. Cdks comprise the catalytic subunit of the cell cycle kinases and they associate with specific regulatory subunits to form an active complex. Cyclin H is one such regulatory subunit that preferentially binds to Cdk7 and forms the cyclin H/Cdk7 complex, which then phosphorylates Cdc2, Cdk2 and Cdk4 to regulate cell cycle progression. Cdk5/p25 is reported to be responsible for the mitotic-like phosphoepitopes present in neurofibrillary tangles and Cdk5 has a critical role in neurodegenerative mechanisms.
- Storage Instruction-80°C
- UNSPSC41106621