ADENOVIRUS-PDGF-R(BETA)

Vector Biolabs

ADENOVIRUS-PDGF-R(BETA)

5

Other Application

Research Use Only

1E10 PFU/ml

The platelet derived growth factor receptor (PDGFR) family comprises PDGFR-(alpha) and PDGFR-(beta), which are structurally related and endowed with protein tyrosine kinase domains. These receptors bind the three PDGF ligand isoforms with different affinities. PDGFR-(alpha) can bind to both A and B subunits of PDGF, while PDGFR-(beta) can only bind the B subunit. Chromosomal translocation of the PDGFR-beta gene is linked with chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.

-80°C

41106621