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ProductsBack/Adezmapimod (Standard) [152121-47-6]

Adezmapimod (Standard) [152121-47-6]

HY-10256R
MedChem Express
CAS Number152121-47-6
Product group Chemicals
Molecular Weight377.43
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Adezmapimod (Standard) [152121-47-6]
  • Delivery Days Customer
    5
  • CAS Number
    152121-47-6
  • Category Supplier
    CHEMICAL,detergents_surfactants
  • Certification
    Research Use Only
  • Molecular Weight
    377.43
  • Scientific Description
    Adezmapimod (Standard) is the analytical standard of Adezmapimod. This product is intended for research and analytical applications. Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38beta2, respectively. Adezmapimod inhibits LCK, GSK3beta and PKBalpha with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator[1][2][3].
  • SMILES
    O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C
  • UNSPSC
    12352005

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