WB analysis of tissue extract (30 ug lysate) of mouse adipose using GTX23455 Adiponectin antibody. Dilution : 2 microg/ml
WB analysis of tissue extract (30 ug lysate) of mouse adipose using GTX23455 Adiponectin antibody. Dilution : 2 microg/ml
Adiponectin antibody
GTX23455
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetAdipoq
Overview
- SupplierGeneTex
- Product NameAdiponectin antibody - Orthogonal Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 2 microg/ml. ICC/IF: 2 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID11450
- Target nameAdipoq
- Target descriptionadiponectin, C1Q and collagen domain containing
- Target synonyms30 kDa adipocyte complement-related protein; 30kDa; a; Acd; Acdc; Acr; Acrp30; Ad; Adid; adip; adipo; adipocyte complement related protein; adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; adipocyte, C1q and collagen domain-containing protein; adipocyte-specific protein AdipoQ; adiponectin; adiponectin d; ap; apM1; APN; GBP2; GBP28
- HostRabbit
- IsotypeIgG
- Protein IDQ60994
- Protein NameAdiponectin
- Scientific DescriptionAdipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin and adiponectin protein of 30 kDa. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, mRNA levels of Adiponectin have been shown to be induced over 100-fold. Studies indicate that Adiponectin enhances the ability of sub-physiological levels of insulin to suppress glucose production, thus linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol-3-kinase (PI3-K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. mRNA levels of Adiponectin have been shown to be significantly reduced in adipose tissue of obese patients with Type 2 diabetes relative to control subjects. Structural similarities to TNFalpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Because Adiponectin is down-regulated in various forms of obesity and its structural similarity to TNFalpha, it is currently being investigated as an important regulator of whole body energy homeostasis.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Genetic and Functional Effects of Adiponectin in Type 2 Diabetes Mellitus Development.Read more
- Skeletal muscle adiponectin induction depends on diet, muscle type/activity, and exercise modality in C57BL/6 mice. Martinez-Huenchullan SF et al., 2018 Oct, Physiol RepRead more
- Differential metabolic effects of constant moderate versus high intensity interval training in high-fat fed mice: possible role of muscle adiponectin. Martinez-Huenchullan SF et al., 2018 Feb, Physiol RepRead more
- Hypogonadism alters cecal and fecal microbiota in male mice. Harada N et al., 2016 Nov, Gut MicrobesRead more