AdipoRon . hydrochloride (water soluble) [924416-43-3]

AdipoGen Life Sciences

AdipoRon . hydrochloride (water soluble)

10

924416-43-3

Research Use Only

>98%

C27H28N2O3 . HCl . H2O

428.5 . 36.5 . 18.0

Chemical. CAS: 924416-43-3 (free base). Formula: C27H28N2O3 . HCl . H2O. MW: 428.5 . 36.5 . 18.0. Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low microm concentration. Activates 5-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. - Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low microm concentration [1, 2]. Activates 5-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells [1]. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism [1]. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms [1]. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet [1]. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice [1].

[Cl-].O=C(COC1=CC=C(C=C1)C(=O)C1=CC=CC=C1)NC1CC[NH+](CC2=CC=CC=C2)CC1

-20°C,2°C to 8°C

12352200