ADL 08-0011 HCl [170098-43-8]

TargetMol Chemicals

ADL 08-0011 HCl [170098-43-8]

44

Chemical

Research Use Only

ADL 08-0011 HCl

C23H30ClNO3

403.947

ADL 08-0011 is an active metabolite of the micro-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a micro-opioid receptor antagonist (Ki = 0.25 nM). It is selective for micro-opioid receptors over kappa- and delta-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.

3 years

Cl.C[C@H]1CN(C[C@H](Cc2ccccc2)C(O)=O)CC[C@@]1(C)c1cccc(O)c1

-20°C

12352200