ADRA1D receptor antagonist 1 (free base) [1191908-24-3]

MedChem Express

ADRA1D receptor antagonist 1 (free base) [1191908-24-3]

10

1191908-24-3

Research Use Only

C15H13ClN4O

300.74

ADRA1D receptor antagonist 1 (free base) (compound (R)-9s) is an orally active, potent and selective human alpha1D-adrenoceptor (alpha1D-AR) antagonist (Ki=1.6 nM). ADRA1D receptor antagonist 1 (free base) dose-dependently inhibits bladder contraction with an IC30 value of 15 nM. ADRA1D receptor antagonist 1 (free base) can be used in studies of overactive bladder disorders such as urinary urgency, frequency and incontinence.

O=C(C1=CC(Cl)=CN([C@@H](C2=CC=CC(C#N)=C2)C)C1=N)N

12131703