AES-350

MedChem Express

AES-350 [847249-57-4]

10

847249-57-4

Research Use Only

99.30

C18H20N2O3

312.36

AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 microM and 0.035 microM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 microM and 0.245 microM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research[1].

O=C(NO)C1=CC=C(NC(C2=CC=C(C(C)(C)C)C=C2)=O)C=C1

2°C to 8°C

12352200