AES-350 [847249-57-4]

TargetMol Chemicals

AES-350 [847249-57-4]

4

847249-57-4

Chemical

Research Use Only

AES-350

0.99

C18H20N2O3

312.36

AES-350 is a potent and orally active HDAC6 inhibitor (IC50 and Ki of 0.0244 microM and 0.035 microM, respectively), also exhibiting activity against HDAC-3, -8, and -11 in an enzymatic assay with IC50 values of 0.187 microM, 0.245 microM, and >1 microM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.

3 years

CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)NO

-20°C

12352200