AF488 Anti-Human CD20 Antibody

Reddot Biotech

AF488 Anti-Human CD20 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

BCA/B20

AlexaFluor 488

MS4A1

membrane spanning 4-domains A1

B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7, B-lymphocyte antigen CD20, B-lymphocyte cell-surface antigen B1, CD20 antigen, CD20 receptor, leukocyte surface antigen Leu-16, membrane-spanning 4-domains, subfamily A, member 1

Mouse

IgG2a

CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.

2°C to 8°C

12352203