AF647 Anti-Mouse CD22 Antibody

Reddot Biotech

AF647 Anti-Mouse CD22 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

Cy34.1

AlexaFluor 647

Cd22

CD22 antigen

A530093D23, Lyb-8, Lyb8, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, T-cell surface antigen Leu-14, sialic acid-binding Ig-like lectin 2, siglec-2

Mouse

IgG1

B-cell receptor CD22

The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig micro chain are augmented in the presence of Cy34.1 mAb. - This is a AF647 Anti-Mouse CD22 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.

Mouse

2°C to 8°C

41116161