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Afatinib dimaleate

M5307
AbMole BioScience
CAS Number850140-73-7
DownloadDatasheet
Product group Chemicals
Estimated Purity1
Molecular Weight717.18
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Afatinib dimaleate
  • Delivery Days Customer
    9
  • CAS Number
    850140-73-7
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Estimated Purity
    1
  • Molecular Formula
    C24H25ClFN5O3.2C4H4O4
  • Molecular Weight
    717.18
  • Scientific Description
    Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
  • SMILES
    CN(C)C/C=C/C(=O)NC1=C(OC2CCOC2)C=C3N=CN=C(NC4=CC=C(F)C(=C4)Cl)C3=C1.OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O
  • UNSPSC
    12352200

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