Afatinib [850140-72-6]

TargetMol Chemicals

Afatinib

9

850140-72-6

Chemical

Research Use Only

Afatinib

97.56%

C24H25ClFN5O3

485.94

Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively.

3 years

N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

-20°C

12352200