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Immunofluorescence analysis of U2OS cells using AFF1 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using AFF1 Polyclonal Antibody
Immunofluorescence analysis of U2OS cells using AFF1 Polyclonal Antibody

AFF1 Polyclonal Antibody

E-AB-61412
Elabscience
Product group Antibodies
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Overview

  • Supplier
    Elabscience
  • Product Name
    AFF1 Polyclonal Antibody
  • Delivery Days Customer
    12
  • Certification
    Research Use Only
  • Scientific Description
    This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
  • UNSPSC
    12352203