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AFM-30a (hydrochloride)

HY-125099A
MedChem Express
Estimated Purity99.96
DownloadMSDS
Product group Chemicals
Molecular Weight502.97
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Overview

  • Supplier
    MedChem Express
  • Product Name
    AFM-30a (hydrochloride)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    99.96
  • Molecular Formula
    C24H28ClFN6O3
  • Molecular Weight
    502.97
  • Scientific Description
    AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC 50 value of 9.5 microM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC 50 value of 0.4 microM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis [1] .
  • SMILES
    O=C(C1=C2C(NCC2=CC=C1)=O)N[C@H](C3=NC4=C(N3C)C=CC=C4OC)CCCNC(CF)=N.[H]Cl
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200