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ProductsBack/AFN-1252 (tosylate) [1047981-31-6]

AFN-1252 (tosylate) [1047981-31-6]

HY-114622
MedChem Express
CAS Number1047981-31-6
Product group Chemicals
Molecular Weight547.62
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Overview

  • Supplier
    MedChem Express
  • Product Name
    AFN-1252 (tosylate) [1047981-31-6]
  • Delivery Days Customer
    9
  • CAS Number
    1047981-31-6
  • Certification
    Research Use Only
  • Molecular Formula
    C29H29N3O6S
  • Molecular Weight
    547.62
  • Scientific Description
    AFN-1252 (API-1252) tosylate is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 tosylate exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 tosylate exhibits typical MIC90 values of 0.015 microg/ml against diverse clinical isolates of S. aureus. AFN-1252 tosylate is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith[1][2].
  • SMILES
    O=S(O)(C1=CC=C(C=C1)C)=O.CC2=C(CN(C)C(/C=C/C(C=C3CC4)=CNC3=NC4=O)=O)OC5=CC=CC=C25
  • UNSPSC
    12352200

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