Aftin-4 [866893-90-5]

TargetMol Chemicals

Aftin-4 [866893-90-5]

4

866893-90-5

Chemical

Research Use Only

Aftin-4

99.03%

C20H28N6O

368.48

Aftin-4, an amyloid forty-two inducer, activates gamma-secretase, promoting the generation of amyloid-beta-1-42 (Abeta1-42) from amyloid-beta protein precursor. Aftin-4(Aftin4) increased Abeta-1-42, but not Abeta-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimers disease-like toxicity in the rodent brain.

3 years

CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1

-20°C

12352200