Afuresertib HCl [1047645-82-8] [1047645-82-8]

Bioss

Afuresertib HCl [1047645-82-8] [1047645-82-8]

16

1047645-82-8

Research Use Only

Unconjugated

98 - 98.0

C18 H18 Cl3 F N4 O S

463.78

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Cl.CN1N=CC(Cl)=C1C1C=C(SC=1Cl)C(=O)N[C@H](CN)CC1=CC(F)=CC=C1

-20°C

12161509