AG-012986 [486414-35-1]

MedChem Express

AG-012986 [486414-35-1]

5

486414-35-1

Research Use Only

99.78

C22H23F2N5O2S

459.51

AG-012986 is a multitargeted CDK inhibitor. AG-012986 is active against CDK1/2/4/6/5/9, with Kis of 9.2 nM (CDK4/cyclin), 94 nM (CDK2/cyclin A), and 44 nM (CDK1/cyclin B), IC50s of 4 nM (CDK9/cyclin T) and 22 nM (CDK5/p35). AG-012986 has antiproliferative activities against cancer cells. AG-012986 induces cell cycle arrest, and apoptosis[1].

O=C(C1=CC=C(C=C1)NC2=NC(N)=C(S2)C(C3=C(C=CC=C3F)F)=O)N[C@@H](CN(C)C)C

-20°C

12352200