AG-205 [442656-02-2]

TargetMol Chemicals

AG-205 [442656-02-2]

44

442656-02-2

Chemical

Research Use Only

AG-205

C22H23ClN6OS

454.98

(rac)-AG-205 serves as a robust inhibitor of the progesterone receptor membrane component 1 (Pgrmc1), crucial for inducing genes linked to sterol synthesis, notably the INSIG1 protein, which interacts with PGRMC1. Additionally, it plays a pivotal role in mitigating neuronal resistance to hypoxic ischaemia by inhibiting NF-kB signalling and the activation of the BDNF/PI3K/AKT pathway.

3 years

CN1CC[C@@H]2[C@H](C1)c1cc(C)ccc1N2C(=O)CSc1nnnn1-c1ccc(Cl)cc1

-20°C

12352200