AG-494

MedChem Express

AG-494 [133550-35-3]

10

133550-35-3

99.31

C16H12N2O3

280.28

AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor ( IC 50 =0.7 microM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC 50 s 1.1, 39, 45 and 6 microM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis [1] [2] [3] .

O=C(NC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2

2°C to 8°C

12352200