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AG-494

HY-101042
MedChem Express
CAS Number133550-35-3
Product group Chemicals
Estimated Purity99.31
Molecular Weight280.28
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Overview

  • Supplier
    MedChem Express
  • Product Name
    AG-494 [133550-35-3]
  • Delivery Days Customer
    10
  • CAS Number
    133550-35-3
  • Certification
    Research Use Only
  • Estimated Purity
    99.31
  • Molecular Formula
    C16H12N2O3
  • Molecular Weight
    280.28
  • Scientific Description
    AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 microM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 microM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].
  • SMILES
    O=C(NC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

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