AG126 [118409-62-4]
T4092
CAS Number118409-62-4
Product group Chemicals
Estimated Purity98.72%
Molecular Weight215.16
Overview
- SupplierTargetMol Chemicals
- Product NameAG126 [118409-62-4]
- Delivery Days Customer9
- CAS Number118409-62-4
- CertificationResearch Use Only
- Chemical NameAG126
- Estimated Purity98.72%
- Molecular FormulaC10H5N3O3
- Molecular Weight215.16
- Scientific DescriptionAG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 microM. It blocks the production of TNF-alpha in vitro2 and in vivo, attenuating signaling through NF-kappaB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 microM) and platelet-derived GFRK (IC50 > 100 microM).
- Shelf life instruction3 years
- SMILESOc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O
- Storage Instruction-20°C
- UNSPSC12352200
MSDS
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