AG126 [118409-62-4]

TargetMol Chemicals

AG126 [118409-62-4]

9

118409-62-4

Chemical

Research Use Only

AG126

98.72%

C10H5N3O3

215.16

AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 microM. It blocks the production of TNF-alpha in vitro2 and in vivo, attenuating signaling through NF-kappaB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 microM) and platelet-derived GFRK (IC50 > 100 microM).

3 years

Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O

-20°C

12352200