AG2034 [177575-17-6]

MedChem Express

AG2034 [177575-17-6]

9

177575-17-6

Research Use Only

C18H21N5O6S2

467.52

AG2034 is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 28 nM against human GARFT, and it binds with high affinity to the folate receptor (Kd of 0.0042 nM). Additionally, AG2034 is a substrate for rat liver folylpolyglutamate synthetase, with a Km of 6.4 microM. AG2034 inhibits the growth of L1210 and CCRF-CEM cells, with IC50 values of 4 nM and 2.9 nM, respectively, and it has demonstrated antitumor activity in xenograft models such as 6C3HED[1][2].

O=C1C2=C(NC(N)=N1)NC[C@@H](S2)CCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)S3

12352200